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Acute interstitial nephritis has been observed in patients taking PPIs including Protonix I.VAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue Protonix I.Vif acute interstitial nephritis developssee Contraindications4

Headache or diarrhea may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

Hematologicleukopeniareported in ex-US clinical trials onlythrombocytopenia.

3Inspect the diluted Protonix I.Vsolution visually for particular matter and discoloration prior to and during administration.

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