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There have been rare reports of adverse reactionsincluding hypertension and dyskinesiaresulting from the concomitant use of tricyclic antidepressants and SINEMET.

Do not stop taking SINEMETor lower the dosagewithout checking with your doctor.

When SINEMET is to be given to patients who are being treated with levodopalevodopa must be discontinued at least twelve hours before therapy with Tretinoin cream purchase SINEMET is startedIn order to reduce adverse reactionsit is necessary to individualize therapySee DOSAGE AND ADMINISTRATION section before initiating therapy.

Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptyingmetoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.

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i was on sinemet for over 3 years , i was worst than ever, went for a second opinion and the doctor took me off sinemet totally, within one week i was feeling so much better, it has been 3 weeks, and i now find out i do not have parkisnson only an essential tremour disorder, made worst by the use of sinemet,it was deadly to me.